A snake venom group IIA PLA(2) with immunomodulatory activity induces formation of lipid droplets containing 15-d-PGJ(2) in macrophages

Crotoxin B (CB) is a catalytically active group IIA sPLA(2) from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA(2)s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with in...

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Vydáno v:Sci Rep
Hlavní autoři: Giannotti, Karina Cristina, Leiguez, Elbio, Carvalho, Ana Eduarda Zulim de, Nascimento, Neide Galvão, Matsubara, Márcio Hideki, Fortes-Dias, Consuelo Latorre, Moreira, Vanessa, Teixeira, Catarina
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481388/
https://ncbi.nlm.nih.gov/pubmed/28642580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04498-8
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