Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model t...

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Foilsithe in:CPT Pharmacometrics Syst Pharmacol
Main Authors: Willmann, Stefan, Frei, Matthias, Sutter, Gabriele, Coboeken, Katrin, Wendl, Thomas, Eissing, Thomas, Lippert, Jörg, Stass, Heino
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2019
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765696/
https://ncbi.nlm.nih.gov/pubmed/31310051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12446
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