Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model t...

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發表在:CPT Pharmacometrics Syst Pharmacol
Main Authors: Willmann, Stefan, Frei, Matthias, Sutter, Gabriele, Coboeken, Katrin, Wendl, Thomas, Eissing, Thomas, Lippert, Jörg, Stass, Heino
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765696/
https://ncbi.nlm.nih.gov/pubmed/31310051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12446
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