Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model t...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Willmann, Stefan, Frei, Matthias, Sutter, Gabriele, Coboeken, Katrin, Wendl, Thomas, Eissing, Thomas, Lippert, Jörg, Stass, Heino
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765696/
https://ncbi.nlm.nih.gov/pubmed/31310051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12446
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