A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

Proteins are an increasingly important class of drugs used as therapeutic as well as diagnostic agents. A generic physiologically based pharmacokinetic (PBPK) model was developed in order to represent at whole body level the fundamental mechanisms driving the distribution and clearance of large mole...

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Dettagli Bibliografici
Pubblicato in:J Pharmacokinet Pharmacodyn
Autori principali: Niederalt, Christoph, Kuepfer, Lars, Solodenko, Juri, Eissing, Thomas, Siegmund, Hans-Ulrich, Block, Michael, Willmann, Stefan, Lippert, Jörg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2017
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845054/
https://ncbi.nlm.nih.gov/pubmed/29234936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-017-9559-4
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