Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study

BACKGROUND: The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. A physiologically based pharmacokinetic (PBPK) model for pediatric rivaroxaban dosing has been constructed...

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Sparad:
Bibliografiska uppgifter
I publikationen:Thromb J
Huvudupphovsmän: Willmann, Stefan, Thelen, Kirstin, Kubitza, Dagmar, Lensing, Anthonie W. A., Frede, Matthias, Coboeken, Katrin, Stampfuss, Jan, Burghaus, Rolf, Mück, Wolfgang, Lippert, Jörg
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2018
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278136/
https://ncbi.nlm.nih.gov/pubmed/30534008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12959-018-0185-1
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