A Physiologically-Based Pharmacokinetic Model to Describe Ciprofloxacin Pharmacokinetics Over the Entire Span of Life

BACKGROUND: Physiologically-based pharmacokinetic (PBPK) modeling has received growing interest as a useful tool for the assessment of drug pharmacokinetics by continuous knowledge integration. OBJECTIVE: The objective of this study was to build a ciprofloxacin PBPK model for intravenous and oral do...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: Schlender, Jan-Frederik, Teutonico, Donato, Coboeken, Katrin, Schnizler, Katrin, Eissing, Thomas, Willmann, Stefan, Jaehde, Ulrich, Stass, Heino
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2018
Schlagworte:
Original Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267540/
https://ncbi.nlm.nih.gov/pubmed/29737457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0661-6
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