Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

BACKGROUND: Because of the vulnerability and frailty of elderly adults, clinical drug development has traditionally been biased towards young and middle-aged adults. Recent efforts have begun to incorporate data from paediatric investigations. Nevertheless, the elderly often remain underrepresented...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Schlender, Jan-Frederik, Meyer, Michaela, Thelen, Kirstin, Krauss, Markus, Willmann, Stefan, Eissing, Thomas, Jaehde, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107207/
https://ncbi.nlm.nih.gov/pubmed/27351180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0422-3
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