The Trials and Tribulations of Structure Assisted Design of K(Ca) Channel Activators

Calcium-activated K(+) channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type K(Ca) activators (SKAs) are K(Ca)3.1 selective we previously generated homology models of the C-terminal calmodulin-bi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Pharmacol
Päätekijät: Shim, Heesung, Brown, Brandon M., Singh, Latika, Singh, Vikrant, Fettinger, James C., Yarov-Yarovoy, Vladimir, Wulff, Heike
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764326/
https://ncbi.nlm.nih.gov/pubmed/31616290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00972
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