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Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)
Intermediate-conductance (K(Ca)3.1) and small-conductance (K(Ca)2) calcium-activated K(+) channels are gated by calcium binding to calmodulin (CaM) molecules associated with the calmodulin-binding domain (CaM-BD) of these channels. The existing K(Ca) activators, such as naphtho[1,2-d]thiazol-2-ylami...
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| Publicado no: | Mol Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5588545/ https://ncbi.nlm.nih.gov/pubmed/28760780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109421 |
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