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Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore
The intermediate-conductance Ca(2+)-activated K(+) channel (KCa3.1) constitutes an attractive pharmacological target for immunosuppression, fibroproliferative disorders, atherosclerosis, and stroke. However, there currently is no available crystal structure of this medically relevant channel that co...
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| Publié dans: | Mol Pharmacol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5363711/ https://ncbi.nlm.nih.gov/pubmed/28126850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.108068 |
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