Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

Severe deficiency of plasma ADAMTS13 activity is the primary cause of thrombotic thrombocytopenic purpura (TTP) whereas overwhelming activation of complement via an alternative pathway results in atypical hemolytic uremic syndrome (aHUS), the prototypes of thrombotic microangiopathy (TMA). However,...

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Vydáno v:Blood
Hlavní autoři: Zheng, Liang, Zhang, Di, Cao, Wenjing, Song, Wen-Chao, Zheng, X. Long
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764266/
https://ncbi.nlm.nih.gov/pubmed/31409673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001040
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