Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

Severe deficiency of plasma ADAMTS13 activity is the primary cause of thrombotic thrombocytopenic purpura (TTP) whereas overwhelming activation of complement via an alternative pathway results in atypical hemolytic uremic syndrome (aHUS), the prototypes of thrombotic microangiopathy (TMA). However,...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zheng, Liang, Zhang, Di, Cao, Wenjing, Song, Wen-Chao, Zheng, X. Long
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764266/
https://ncbi.nlm.nih.gov/pubmed/31409673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001040
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