Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP) is primarily caused by immunoglobulin G (IgG) autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin type 1 repeats, 13 (ADAMTS13). Nearly all adult idiopathic TTP patients harbor IgGs, which bind the spacer domain of ADAMTS13, a region...

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Detalhes bibliográficos
Main Authors: Jian, Cui, Xiao, Juan, Gong, Lingjie, Skipwith, Christopher G., Jin, Sheng-Yu, Kwaan, Hau C., Zheng, X. Long
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335387/
https://ncbi.nlm.nih.gov/pubmed/22289888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-399501
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