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Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

BACKGROUND: Type G immunoglobulins against ADAMTS13 are the primary cause of acquired (idiopathic) thrombotic thrombocytopenic purpura. However, the domains of ADAMTS13 which the type G anti-ADAMT13 immunoglobulins target have not been investigated in a large cohort of patients with thrombotic throm...

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Detalhes bibliográficos
Main Authors: Zheng, X. Long, Wu, Haifeng M., Shang, Dezhi, Falls, Erica, Skipwith, Christopher G., Cataland, Spero R., Bennett, Charles L., Kwaan, Hau C.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930958/
https://ncbi.nlm.nih.gov/pubmed/20378566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.019299
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