Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult

Brain lesions containing filamentous and aggregated α-synuclein are hallmarks of neurodegenerative synucleinopathies. Oxidative stress has been implicated in the formation of these lesions. Using HEK 293 cells stably transfected with wild-type and mutant α-synuclein, we demonstrated that intracellul...

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發表在:J Neurosci
Main Authors: Paxinou, Evgenia, Chen, Qiping, Weisse, Marie, Giasson, Benoit I., Norris, Erin H., Rueter, Susan M., Trojanowski, John Q., Lee, Virginia M.-Y., Ischiropoulos, Harry
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763872/
https://ncbi.nlm.nih.gov/pubmed/11588178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-20-08053.2001
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