Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease

BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a hematologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias, and life-threatening multi-organ dysfunction. The molecular underpinnings of interleukin-6 (IL-6) blockade–refractory patients rema...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Fajgenbaum, David C., Langan, Ruth-Anne, Japp, Alberto Sada, Partridge, Helen L., Pierson, Sheila K., Singh, Amrit, Arenas, Daniel J., Ruth, Jason R., Nabel, Christopher S., Stone, Katie, Okumura, Mariko, Schwarer, Anthony, Jose, Fábio Freire, Hamerschlak, Nelson, Wertheim, Gerald B., Jordan, Michael B., Cohen, Adam D., Krymskaya, Vera, Rubenstein, Arthur, Betts, Michael R., Kambayashi, Taku, van Rhee, Frits, Uldrick, Thomas S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Clinical Medicine
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763254/
https://ncbi.nlm.nih.gov/pubmed/31408438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126091
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