Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease

BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a hematologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias, and life-threatening multi-organ dysfunction. The molecular underpinnings of interleukin-6 (IL-6) blockade–refractory patients rema...

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書目詳細資料
發表在:J Clin Invest
Main Authors: Fajgenbaum, David C., Langan, Ruth-Anne, Japp, Alberto Sada, Partridge, Helen L., Pierson, Sheila K., Singh, Amrit, Arenas, Daniel J., Ruth, Jason R., Nabel, Christopher S., Stone, Katie, Okumura, Mariko, Schwarer, Anthony, Jose, Fábio Freire, Hamerschlak, Nelson, Wertheim, Gerald B., Jordan, Michael B., Cohen, Adam D., Krymskaya, Vera, Rubenstein, Arthur, Betts, Michael R., Kambayashi, Taku, van Rhee, Frits, Uldrick, Thomas S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Clinical Medicine
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763254/
https://ncbi.nlm.nih.gov/pubmed/31408438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126091
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