Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease

BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a hematologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias, and life-threatening multi-organ dysfunction. The molecular underpinnings of interleukin-6 (IL-6) blockade–refractory patients rema...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Fajgenbaum, David C., Langan, Ruth-Anne, Japp, Alberto Sada, Partridge, Helen L., Pierson, Sheila K., Singh, Amrit, Arenas, Daniel J., Ruth, Jason R., Nabel, Christopher S., Stone, Katie, Okumura, Mariko, Schwarer, Anthony, Jose, Fábio Freire, Hamerschlak, Nelson, Wertheim, Gerald B., Jordan, Michael B., Cohen, Adam D., Krymskaya, Vera, Rubenstein, Arthur, Betts, Michael R., Kambayashi, Taku, van Rhee, Frits, Uldrick, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763254/
https://ncbi.nlm.nih.gov/pubmed/31408438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126091
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