Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type I IFN controls the cellular citrate/α-ketoglutarate ratio and inhibits expression and...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: De Souza, David P., Achuthan, Adrian, Lee, Man K.S., Binger, Katrina J., Lee, Ming-Chin, Davidson, Sophia, Tull, Dedreia L., McConville, Malcolm J., Cook, Andrew D., Murphy, Andrew J., Hamilton, John A., Fleetwood, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763227/
https://ncbi.nlm.nih.gov/pubmed/31483287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127597
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