Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type I IFN controls the cellular citrate/α-ketoglutarate ratio and inhibits expression and...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: De Souza, David P., Achuthan, Adrian, Lee, Man K.S., Binger, Katrina J., Lee, Ming-Chin, Davidson, Sophia, Tull, Dedreia L., McConville, Malcolm J., Cook, Andrew D., Murphy, Andrew J., Hamilton, John A., Fleetwood, Andrew J.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Concise Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763227/
https://ncbi.nlm.nih.gov/pubmed/31483287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127597
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