Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type I IFN controls the cellular citrate/α-ketoglutarate ratio and inhibits expression and...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: De Souza, David P., Achuthan, Adrian, Lee, Man K.S., Binger, Katrina J., Lee, Ming-Chin, Davidson, Sophia, Tull, Dedreia L., McConville, Malcolm J., Cook, Andrew D., Murphy, Andrew J., Hamilton, John A., Fleetwood, Andrew J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2019
主題:
Concise Communication
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763227/
https://ncbi.nlm.nih.gov/pubmed/31483287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127597
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