Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells

The TCA cycle is the central hub of oxidative metabolism, running in the classic forward direction to provide carbon for biosynthesis and reducing agents for generation of ATP. Our metabolic tracer studies in melanoma cells showed that in hypoxic conditions the TCA cycle is largely disconnected from...

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Detaylı Bibliyografya
Asıl Yazarlar: Filipp, Fabian V., Scott, David A., Ronai, Ze’ev A., Osterman, Andrei L., Smith, Jeffrey W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329592/
https://ncbi.nlm.nih.gov/pubmed/22360810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2012.00989.x
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