Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

Glutamine dependence is a prominent feature of cancer metabolism, and here we show that melanoma cells, irrespective of their oncogenic background, depend on glutamine for growth. A quantitative audit of how carbon from glutamine is used showed that TCA-cycle-derived glutamate is, in most melanoma c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Ratnikov, Boris, Aza-Blanc, Pedro, Ronai, Ze'ev A., Smith, Jeffrey W., Osterman, Andrei L., Scott, David A.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Priority Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480687/
https://ncbi.nlm.nih.gov/pubmed/25749035
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