Functional Specialization in Proline Biosynthesis of Melanoma

Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then t...

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Detalhes bibliográficos
Main Authors: De Ingeniis, Jessica, Ratnikov, Boris, Richardson, Adam D., Scott, David A., Aza-Blanc, Pedro, De, Surya K., Kazanov, Marat, Pellecchia, Maurizio, Ronai, Ze'ev, Osterman, Andrei L., Smith, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443215/
https://ncbi.nlm.nih.gov/pubmed/23024808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045190
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