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An allosteric network in spastin couples multiple activities required for microtubule severing
The AAA+ ATPase spastin remodels microtubule arrays through severing, and its mutation is the most common cause of hereditary spastic paraplegias (HSP). Polyglutamylation of the tubulin C-terminal tail recruits spastin to microtubules and modulates severing activity. Here, we present a ~3.2 Å resolu...
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| Published in: | Nat Struct Mol Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6761829/ https://ncbi.nlm.nih.gov/pubmed/31285604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0257-3 |
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