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Inferring the “Primordial Immune Complex”: Origins of MHC class I and antigen receptors revealed by comparative genomics

Comparative analyses suggest that the MHC was derived from a pre-vertebrate “Primordial Immune Complex” (PIC). PIC duplicated twice in the well-studied two rounds of genome-wide duplications (2R) early in vertebrate evolution, generating four MHC paralogous regions (predominantly on human chromosome...

詳細記述

保存先:
書誌詳細
出版年:J Immunol
主要な著者: Ohta, Yuko, Kasahara, Masanori, O’Connor, Timothy D., Flajnik, Martin F.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761025/
https://ncbi.nlm.nih.gov/pubmed/31492741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900597
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