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Inferring the “Primordial Immune Complex”: Origins of MHC class I and antigen receptors revealed by comparative genomics
Comparative analyses suggest that the MHC was derived from a pre-vertebrate “Primordial Immune Complex” (PIC). PIC duplicated twice in the well-studied two rounds of genome-wide duplications (2R) early in vertebrate evolution, generating four MHC paralogous regions (predominantly on human chromosome...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6761025/ https://ncbi.nlm.nih.gov/pubmed/31492741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900597 |
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