Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines

Ewing Sarcoma (ES) is characterized by recurrent translocations between EWSR1 and members of the ETS family of transcription factors. The transcriptional activity of the fusion oncoprotein is dependent on interaction with the nucleosome remodeling and deactylase (NuRD) co-repressor complex. While in...

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Veröffentlicht in:PLoS One
Hauptverfasser: Welch, Darcy, Kahen, Elliot, Fridley, Brooke, Brohl, Andrew S., Cubitt, Christopher L., Reed, Damon R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759167/
https://ncbi.nlm.nih.gov/pubmed/31550266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222228
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