Selective Blockade of mGlu5 Metabotropic Glutamate Receptors Is Protective against Methamphetamine Neurotoxicity

Methamphetamine (MA), a widely used drug of abuse, produces oxidative damage of nigrostriatal dopaminergic terminals. We examined the effect of subtype-selective ligands of metabotropic glutamate (mGlu) receptors on MA neurotoxicity in mice. MA (5 mg/kg, i.p.; injected three times, every 2 hr) induc...

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Publié dans:J Neurosci
Auteurs principaux: Battaglia, Giuseppe, Fornai, Francesco, Busceti, Carla L., Aloisi, Gabriella, Cerrito, Franca, De Blasi, Antonio, Melchiorri, Daniela, Nicoletti, Ferdinando
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2002
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ARTICLE
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758277/
https://ncbi.nlm.nih.gov/pubmed/11896153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-06-02135.2002
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