mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

Group II metabotropic glutamate receptors (mGluRs) couple to the inhibitory G-protein Gi. The group II mGluRs include two subtypes, mGlu2 and mGlu3, and their pharmacological activation produces analgesic effects in inflammatory and neuropathic pain states. However, the specific contribution of each...

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Main Authors: Zammataro, Magda, Chiechio, Santina, Montana, Michael C, Traficante, Anna, Copani, Agata, Nicoletti, Ferdinando, Gereau, Robert W
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Short Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030510/
https://ncbi.nlm.nih.gov/pubmed/21235748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-6
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