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Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death

Barbiturates are widely used as anesthetics, anticonvulsants, and neuroprotective agents. However, barbiturates may also inhibit mitochondrial respiration, and mitochondrial inhibitors are known to potentiate NMDA receptor-mediated neurotoxicity. Here we used rat cortical cultures to examine the eff...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Anderson, Christopher M., Norquist, Becky A., Vesce, Sabino, Nicholls, David G., Soine, William H., Duan, Shumin, Swanson, Raymond A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758030/
https://ncbi.nlm.nih.gov/pubmed/12417645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-21-09203.2002
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