Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels. Although pharmacologic modulation of excitatory amino acid receptors is well studied, minimal consideration has been given to targeting mitochondrial...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Divakaruni, Ajit S., Wallace, Martina, Buren, Caodu, Martyniuk, Kelly, Andreyev, Alexander Y., Li, Edward, Fields, Jerel A., Cordes, Thekla, Reynolds, Ian J., Bloodgood, Brenda L., Raymond, Lynn A., Metallo, Christian M., Murphy, Anne N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379957/
https://ncbi.nlm.nih.gov/pubmed/28254829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612067
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