Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels. Although pharmacologic modulation of excitatory amino acid receptors is well studied, minimal consideration has been given to targeting mitochondrial...

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Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Divakaruni, Ajit S., Wallace, Martina, Buren, Caodu, Martyniuk, Kelly, Andreyev, Alexander Y., Li, Edward, Fields, Jerel A., Cordes, Thekla, Reynolds, Ian J., Bloodgood, Brenda L., Raymond, Lynn A., Metallo, Christian M., Murphy, Anne N.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379957/
https://ncbi.nlm.nih.gov/pubmed/28254829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612067
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