Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels. Although pharmacologic modulation of excitatory amino acid receptors is well studied, minimal consideration has been given to targeting mitochondrial...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Divakaruni, Ajit S., Wallace, Martina, Buren, Caodu, Martyniuk, Kelly, Andreyev, Alexander Y., Li, Edward, Fields, Jerel A., Cordes, Thekla, Reynolds, Ian J., Bloodgood, Brenda L., Raymond, Lynn A., Metallo, Christian M., Murphy, Anne N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379957/
https://ncbi.nlm.nih.gov/pubmed/28254829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612067
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