Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death

Barbiturates are widely used as anesthetics, anticonvulsants, and neuroprotective agents. However, barbiturates may also inhibit mitochondrial respiration, and mitochondrial inhibitors are known to potentiate NMDA receptor-mediated neurotoxicity. Here we used rat cortical cultures to examine the eff...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Anderson, Christopher M., Norquist, Becky A., Vesce, Sabino, Nicholls, David G., Soine, William H., Duan, Shumin, Swanson, Raymond A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758030/
https://ncbi.nlm.nih.gov/pubmed/12417645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-21-09203.2002
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