Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death
Excessive activation of poly(ADP-ribose) polymerase 1 (PARP1) leads to NAD(+) depletion and cell death during ischemia and other conditions that generate extensive DNA damage. When activated by DNA strand breaks, PARP1 uses NAD(+) as substrate to form ADP-ribose polymers on specific acceptor protein...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC59796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11593040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211202598 |
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