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A strategy for the selection of monovalent antibodies that span protein dimer interfaces
Ligand-induced dimerization is the predominant mechanism through which secreted proteins activate cell surface receptors to transmit essential biological signals. Cytokines are a large class of soluble proteins that dimerize transmembrane receptors into precise signaling topologies, but there is a n...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6755802/ https://ncbi.nlm.nih.gov/pubmed/31387945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009213 |
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