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Antibodies to Interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates immune cell homeostasis, and has been used to treat a range of disorders such as cancer and autoimmune disease. IL-2 signals via interleukin-2 receptor-β (IL-2Rβ):IL-2Rγ heterodimers on cells expressing high (regulatory T cells, Treg) or...
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| 出版年: | Immunity |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4439582/ https://ncbi.nlm.nih.gov/pubmed/25992858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.04.015 |
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