Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation. However, the number of receptor dimer pairings occurring in nature is limited to those driven by na...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Moraga, Ignacio, Spangler, Jamie B, Mendoza, Juan L, Gakovic, Milica, Wehrman, Tom S, Krutzik, Peter, Garcia, K Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429090/
https://ncbi.nlm.nih.gov/pubmed/28498099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22882
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