Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity

Selective inhibition of tumor necrosis factor (TNF) signaling through the proinflammatory axis of TNF-receptor 1 (TNFR1) while leaving pro-survival and regeneration-promoting signals via TNFR2 unaffected is a promising strategy to circumvent limitations of complete inhibition of TNF action by the ap...

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Foilsithe in:MAbs
Main Authors: Richter, Fabian, Zettlitz, Kirstin A., Seifert, Oliver, Herrmann, Andreas, Scheurich, Peter, Pfizenmaier, Klaus, Kontermann, Roland E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2018
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343807/
https://ncbi.nlm.nih.gov/pubmed/30252601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1524664
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