DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response

DNA-dependent protein kinase catalytic subunit (-PKcs) is the core protein involved in the non-homologous end-joining repair of double-strand breaks. In addition, it can form a complex with poly(ADP-ribose) polymerase 1 (PARP1), which catalyzes protein PARylation. However, it is unclear how DNA-PKcs...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Med Rep
Auteurs principaux: Han, Yang, Jin, Feng, Xie, Ying, Liu, Yike, Hu, Sai, Liu, Xiao-Dan, Guan, Hua, Gu, Yongqing, Ma, Teng, Zhou, Ping-Kun
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2019
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755157/
https://ncbi.nlm.nih.gov/pubmed/31485633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2019.10640
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