HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is the core component of DNA-PK complex in the non-homologous end-joining (NHEJ) repair of DNA double-strand breaks, and its activity is strictly controlled by DNA-PKcs phosphorylation. The ubiquitin-like protein, NEDD8 is involved in regulat...

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Publicado no:Cell Death Dis
Main Authors: Guo, Zongpei, Wang, Shaozheng, Xie, Ying, Han, Yang, Hu, Sai, Guan, Hua, Xie, Dafei, Bai, Chenjun, Liu, Xiaodan, Gu, Yongqing, Zhou, Ping-Kun, Ma, Teng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250858/
https://ncbi.nlm.nih.gov/pubmed/32457294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2611-0
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