TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy

Nonhomologous end joining (NHEJ) and homologous recombination (HR) are major repair pathways of DNA double-strand breaks (DSBs). The pathway choice of HR and NHEJ is tightly regulated in cellular response to DNA damage. Here, we demonstrate that the interaction of TIP60 with DNA-PKcs is attenuated s...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Gao, Shan-Shan, Guan, Hua, Yan, Shuang, Hu, Sai, Song, Man, Guo, Zong-Pei, Xie, Da-Fei, Liu, Yike, Liu, Xiaodan, Zhang, Shimeng, Zhou, Ping-Kun
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439314/
https://ncbi.nlm.nih.gov/pubmed/32832608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba7822
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