Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation

The XPF-ERCC1 heterodimer is a structure-specific endonuclease that is essential for nucleotide excision repair (NER) and interstrand crosslink (ICL) repair in mammalian cells. However, whether and how XPF binding to ERCC1 is regulated has not yet been established. Here, we show that TIP60, also kno...

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Publicado no:Nat Commun
Main Authors: Wang, Jiajia, He, Hanqing, Chen, Binbin, Jiang, Guixing, Cao, Liping, Jiang, Haiping, Zhang, Guofei, Chen, Jianxiang, Huang, Jun, Yang, Bing, Zhou, Chun, Liu, Ting
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005904/
https://ncbi.nlm.nih.gov/pubmed/32034146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14564-x
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