Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins

Anti-CRISPR proteins Acrs targeting CRISPR-Cas9 systems represent natural “off-switches” for Cas9-based applications. Recently, AcrIIC1, AcrIIC2, and AcrIIC3 proteins were found to inhibit Neisseria meningitidis Cas9 (NmeCas9) activity in bacterial and human cells. Here we report biochemical and str...

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Dettagli Bibliografici
Pubblicato in:Mol Cell
Autori principali: Zhu, Yalan, Gao, Ang, Zhan, Qi, Wang, Yong, Feng, Han, Liu, Songqing, Gao, Guangxia, Serganov, Alexander, Gao, Pu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750902/
https://ncbi.nlm.nih.gov/pubmed/30850331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.038
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