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Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins
Anti-CRISPR proteins Acrs targeting CRISPR-Cas9 systems represent natural “off-switches” for Cas9-based applications. Recently, AcrIIC1, AcrIIC2, and AcrIIC3 proteins were found to inhibit Neisseria meningitidis Cas9 (NmeCas9) activity in bacterial and human cells. Here we report biochemical and str...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6750902/ https://ncbi.nlm.nih.gov/pubmed/30850331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.038 |
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