Disabling Cas9 by an anti-CRISPR DNA mimic

CRISPR (clustered regularly interspaced short palindromic repeats)–Cas9 gene editing technology is derived from a microbial adaptive immune system, where bacteriophages are often the intended target. Natural inhibitors of CRISPR-Cas9 enable phages to evade immunity and show promise in controlling Ca...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Shin, Jiyung, Jiang, Fuguo, Liu, Jun-Jie, Bray, Nicolas L., Rauch, Benjamin J., Baik, Seung Hyun, Nogales, Eva, Bondy-Denomy, Joseph, Corn, Jacob E., Doudna, Jennifer A.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507636/
https://ncbi.nlm.nih.gov/pubmed/28706995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1701620
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