Inhibition of CRISPR-Cas9 with Bacteriophage Proteins

Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend against bacteriophage infection. As a counter-measure, numerous phages are known that produce proteins to block the function of Class 1 CRISPR-Cas systems. However, currently no proteins are known to inhibit the wi...

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Bibliographic Details
Published in:Cell
Main Authors: Rauch, Benjamin J., Silvis, Melanie R., Hultquist, Judd F., Waters, Christopher S., McGregor, Michael J., Krogan, Nevan J., Bondy-Denomy, Joseph
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5235966/
https://ncbi.nlm.nih.gov/pubmed/28041849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.009
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