Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation

In response to cellular stresses, activating transcriptional factor 4 (ATF4) regulates the expression of both stress-relieving genes and apoptosis-inducing genes, eliciting cell fate determination. Since pharmacological activation of ATF4 exerts potent anti-tumor effects, modulators of ATF4 activati...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Nishikawa, Sakiko, Itoh, Yuka, Tokugawa, Muneshige, Inoue, Yasumichi, Nakashima, Ken-ichi, Hori, Yuka, Miyajima, Chiharu, Yoshida, Kou, Morishita, Daisuke, Ohoka, Nobumichi, Inoue, Makoto, Mizukami, Hajime, Makino, Toshiaki, Hayashi, Hidetoshi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749437/
https://ncbi.nlm.nih.gov/pubmed/31461933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24173110
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