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Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway

The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death in response to various cellular stresses, thereby preventing cancer development. Therefore, the activation of p53 through small molecules is an attractive therapeutic strategy for the treatment of cancers...

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發表在:Molecules
Main Authors: Nagasaka, Mai, Hashimoto, Ryoko, Inoue, Yasumichi, Ishiuchi, Kan’ichiro, Matsuno, Michiyo, Itoh, Yuka, Tokugawa, Muneshige, Ohoka, Nobumichi, Morishita, Daisuke, Mizukami, Hajime, Makino, Toshiaki, Hayashi, Hidetoshi
格式: Artigo
語言:Inglês
出版: MDPI 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099937/
https://ncbi.nlm.nih.gov/pubmed/29890668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23061394
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