The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21

Su(var)3–9, Enhancer-of-zeste, and Trithorax (SET) domain-containing protein 8 (SET8) is the sole enzyme that monomethylates Lys-20 of histone H4 (H4K20). SET8 has been implicated in the regulation of multiple biological processes, such as gene transcription, the cell cycle, and senescence. SET8 qui...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Fukuura, Keishi, Inoue, Yasumichi, Miyajima, Chiharu, Watanabe, Shin, Tokugawa, Muneshige, Morishita, Daisuke, Ohoka, Nobumichi, Komada, Masayuki, Hayashi, Hidetoshi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Protein Synthesis and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827320/
https://ncbi.nlm.nih.gov/pubmed/31533987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009006
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