Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence

Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell proliferation and anti-apoptotic genes in ord...

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Published in:Cells
Main Authors: Miyajima, Chiharu, Kawarada, Yuki, Inoue, Yasumichi, Suzuki, Chiaki, Mitamura, Kana, Morishita, Daisuke, Ohoka, Nobumichi, Imamura, Takeshi, Hayashi, Hidetoshi
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016652/
https://ncbi.nlm.nih.gov/pubmed/31936650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9010171
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